KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
|
Home
|
Kinexus
|
Contact
|
Credits
Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
CHEK2
All Species:
21.52
Human Site:
S260
Identified Species:
33.81
UniProt:
O96017
Number Species:
14
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O96017
NP_001005735.1
543
60915
S260
K
R
K
F
A
I
G
S
A
R
E
A
D
P
A
Chimpanzee
Pan troglodytes
XP_001172779
543
60866
S260
K
R
K
F
A
I
G
S
A
R
E
A
D
P
A
Rhesus Macaque
Macaca mulatta
XP_001102484
543
60923
S260
K
R
K
F
A
I
G
S
A
R
E
T
D
P
A
Dog
Lupus familis
XP_543464
544
61233
S261
K
R
K
F
A
I
G
S
E
R
E
A
D
P
A
Cat
Felis silvestris
Mouse
Mus musculus
Q9Z265
546
61070
S264
K
R
R
F
A
L
G
S
S
R
E
A
D
T
A
Rat
Rattus norvegicus
NP_446129
545
60912
S263
K
R
R
F
A
L
G
S
S
R
E
A
D
T
A
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001508699
537
60493
E253
Q
S
V
E
T
E
I
E
I
L
K
K
L
N
H
Chicken
Gallus gallus
NP_001073576
522
58779
I257
E
I
E
I
L
K
K
I
D
H
P
C
L
I
K
Frog
Xenopus laevis
NP_001082016
517
58243
L251
E
I
E
I
L
K
K
L
D
H
P
C
I
I
K
Zebra Danio
Brachydanio rerio
Q501V0
422
47914
L178
E
L
A
T
G
G
E
L
F
D
R
I
I
T
R
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
O61267
476
54243
K233
L
N
E
A
K
I
M
K
N
L
S
H
P
C
V
Honey Bee
Apis mellifera
XP_624334
480
54300
I236
C
I
I
R
M
E
E
I
V
D
T
P
K
A
V
Nematode Worm
Caenorhab. elegans
Q9U1Y5
476
53320
N233
M
K
K
L
S
H
P
N
I
V
A
I
Y
D
W
Sea Urchin
Strong. purpuratus
XP_794585
480
52849
I236
R
L
H
H
P
C
I
I
G
I
E
D
V
C
D
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P39009
513
58614
N250
K
Q
F
R
E
E
T
N
I
L
M
R
V
Q
H
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.8
99
89.3
N.A.
83.1
83.4
N.A.
74.4
67.5
59.6
28.1
N.A.
34
37.2
30.2
43.2
Protein Similarity:
100
99.8
99
93
N.A.
89.7
89.9
N.A.
82.1
77.9
73.1
41.9
N.A.
51.5
54.5
49.5
58.3
P-Site Identity:
100
100
93.3
93.3
N.A.
73.3
73.3
N.A.
0
0
0
0
N.A.
6.6
0
6.6
6.6
P-Site Similarity:
100
100
93.3
93.3
N.A.
93.3
93.3
N.A.
13.3
13.3
13.3
6.6
N.A.
13.3
0
26.6
13.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
28.3
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
47.1
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
6.6
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
20
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
7
7
40
0
0
0
20
0
7
34
0
7
40
% A
% Cys:
7
0
0
0
0
7
0
0
0
0
0
14
0
14
0
% C
% Asp:
0
0
0
0
0
0
0
0
14
14
0
7
40
7
7
% D
% Glu:
20
0
20
7
7
20
14
7
7
0
47
0
0
0
0
% E
% Phe:
0
0
7
40
0
0
0
0
7
0
0
0
0
0
0
% F
% Gly:
0
0
0
0
7
7
40
0
7
0
0
0
0
0
0
% G
% His:
0
0
7
7
0
7
0
0
0
14
0
7
0
0
14
% H
% Ile:
0
20
7
14
0
34
14
20
20
7
0
14
14
14
0
% I
% Lys:
47
7
34
0
7
14
14
7
0
0
7
7
7
0
14
% K
% Leu:
7
14
0
7
14
14
0
14
0
20
0
0
14
0
0
% L
% Met:
7
0
0
0
7
0
7
0
0
0
7
0
0
0
0
% M
% Asn:
0
7
0
0
0
0
0
14
7
0
0
0
0
7
0
% N
% Pro:
0
0
0
0
7
0
7
0
0
0
14
7
7
27
0
% P
% Gln:
7
7
0
0
0
0
0
0
0
0
0
0
0
7
0
% Q
% Arg:
7
40
14
14
0
0
0
0
0
40
7
7
0
0
7
% R
% Ser:
0
7
0
0
7
0
0
40
14
0
7
0
0
0
0
% S
% Thr:
0
0
0
7
7
0
7
0
0
0
7
7
0
20
0
% T
% Val:
0
0
7
0
0
0
0
0
7
7
0
0
14
0
14
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
7
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
7
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _